Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Although task-unrelated thinking has been increasingly investigated in recent years, the content and correlates of everyday off-task thought in clinical d...

The traces of real, that is, ancient, rival versions of Terence's lines are not so pronounced as of Plautus' lines. Professor Lindsay has drawn attention to a possible instance at Hec. 468 . Another seems to be Andr. 532 , if I am right in supposing that the text used by Donatus had ipsum Chremem. A trace of the variant survives in the unmetrical δ-setting ipsum obuiam Chremem DGL. The text of the other minuscule MSS. has ipsum obuiam. A (...) is not in evidence for this part of Andria. Had it too ipsum Chremem ? (shrink)

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...) dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’. (shrink)

This paper provides a philosophical critique of professional stereotypes in medicine. In the course of this critique, we also offer a detailed analysis of the concept of care in health care. The paper first considers possible explanations for the traditional stereotype that caring is a province of nurses and women, while curing is an arena suited for physicians and men. It then dispels this stereotype and fine tunes the concept of care. A distinction between ‘caring for’ and ‘caring about’ is (...) made, and concomitant notions of parentalism are elaborated. Finally, the paper illustrates, through the use of cases, diverse models of caring. Our discussion reveals the complexity of care and the alternative modes of caring in health care. (shrink)

For over a century we have attempted to understand human aesthetic experience using scientific methods. A typical experiment could be described as reductive and quasi-psychophysical. We vary some aspect of the stimulus and systematically measure some aspect of the aesthetic response. The limitations of this approach can be categorized as problems on the Y axis and the X axis. The most enigmatic components of aesthetic experience include inclination to cry, aesthetic rapture, a sense of the sublime, and intense fascination. However, (...) we cannot evoke these 'hot' aesthetic emotions in the lab, at least not with well controlled stimuli on multiple trials. We thus resort to measuring cold, cognitive preference ratings. There are also problems on the X axis. The reductive psychophysical approach explicitly assumes that there are lawful relations between different stimulus dimensions and preferences. It also tacitly assumes that these dimensions are independent and orthogonal. The second assumption is implausible. Whatever stimulus-preference laws we discover are likely to be twisted and modulated when another dimension is added to the stimuli. This 'gestalt nightmare' has long been recognized, but never resolved. This matters, because human aesthetic faculties are probably tuned to the balance and relationship of parts which make up a whole and are indifferent to the parts presented in isolation. I conclude that the future of scientific aesthetics depends on how successfully we can transcend reductive, quasi-psychophysical approaches. (shrink)

In Plautus and elsewhere in old Latin there is an imperative suffix -mino of medio-deponential meaning: opperimino, PL True. 188, progredimino, id. Pseud. 859, arbitramino, id. Epid. 695, praefamino, Cato, RR. 141, 2, famino Paul. Fest. 62, 10, Th., all 2 sg.; in legal documents, antestamino, in the XII Tables, fruimino, CIL. 1, 199, profitemino in Lex Iulia Municipalis, all 3 sg. The generally accepted explanation of the form is that it arose from a contamination of the ordinary 2 pl. (...) medio-passive imperative in -mini and the 2, 3 sg. forms in -to, Lindsay, Latin Language, p. 517, Von Planta, Gramm. d. oskisch-umbr. Dial. II, pp. 310 sqq., Buck, Elementarb. d. oskisch-umbr. Dial. p. 112, Sommer, Hdb. d. lat. Laut- u. Formenlehre, p. 366, Stolz, Lat. Gramm*. p. 158. The Oskan and the Umbrian forms in -mo, -mu, U. spahamu, eturstahmu, persnimu, O. censamur, all of 2 or 3 sg., and U. arsmahamo, caterahamo of 2 or 3 pi., are identified with the Lat. -minō forms on the assumption that the Osk-Umbr. -mu represents an older *-mnō which in turn arose by syncope from -*menō Von Planta, l.c. This explanation is the most satisfactory that has been given, and we may suppose that Latin, Oskan, and Umbrian had an imperative form in *-menō. (shrink)

The Dutch system of obstetric care is often recommended for midwife-attended births, the high number of home deliveries, and the low rate of intervention during pregnancy and labour. In this contribution, the question is addressed whether processes of medicalization can be demonstrated in the Dutch midwife practice. Medicalization of pregnancy and childbirth is often criticized because it creates dependency on the medical system and infringement of the autonomy of pregnant women. It is concluded that medicalization is present in the practice (...) of Dutch independent midwives, however it is less clear and outspoken than in hospital policies. (shrink)

In Plautus and elsewhere in old Latin there is an imperative suffix -mino of medio-deponential meaning: opperimino, PL True. 188 , progredimino, id. Pseud. 859, arbitramino, id. Epid. 695, praefamino, Cato, RR. 141, 2, famino Paul. Fest. 62, 10, Th., all 2 sg.; in legal documents, antestamino , in the XII Tables, fruimino , CIL. 1, 199, profitemino in Lex Iulia Municipalis, all 3 sg. The generally accepted explanation of the form is that it arose from a contamination of the (...) ordinary 2 pl. medio-passive imperative in -mini and the 2, 3 sg. forms in -to, Lindsay, Latin Language, p. 517, Von Planta, Gramm. d. oskisch-umbr. Dial. II, pp. 310 sqq., Buck, Elementarb. d. oskisch-umbr. Dial. p. 112, Sommer, Hdb. d. lat. Laut- u. Formenlehre, p. 366, Stolz, Lat. Gramm*. p. 158. The Oskan and the Umbrian forms in -mo, -mu, U. spahamu, eturstahmu, persnimu, O. censamur, all of 2 or 3 sg., and U. arsmahamo, caterahamo of 2 or 3 pi., are identified with the Lat. -minō forms on the assumption that the Osk-Umbr. -mu represents an older *-mnō which in turn arose by syncope from -*menō Von Planta, l.c. This explanation is the most satisfactory that has been given, and we may suppose that Latin, Oskan, and Umbrian had an imperative form in *-menō. (shrink)

Available in paperback for the first time, this landmark volume examines the course of Western philosophy over the past 2,500 years. A Critical History of Western Philosophy focuses on the most significant thinkers and philosophical movements while emphasizing key ideas of permanent interest and relevance. Arranged chronologically from early Greece to the twentieth century, this comprehensive work includes expert histories of all major figures from Socrates and Plato to G.E. Moore and Bertrand Russell, and of every important school from the (...) Epicureans to the Existentialists. (shrink)

We use a result due to Rolin, Speissegger, and Wilkie to show that definable sets in certain o-minimal structures admit definable parameterizations by mild maps. We then use this parameterization to prove a result on the density of rational points on curves defined by restricted Pfaffian functions.

Psychiatric diagnosis and prognosis is fraught with important philosophical and conceptual problems. This chapter focuses on some epistemological issues and moral issues that arise in contemporary psychiatric practice. It examines various clinical and actuarial techniques for psychiatric diagnosis, ordered very loosely in terms of how "structured" or "automated" they are. The chapter makes the case for assessing psychiatric treatments with controlled experiments, raises several epistemological dangers that arise from relying on uncontrolled investigations, and considers some of the unique methodological and (...) ethical issues that arise when trying to assess talk therapy. (shrink)